BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 for a broad range of

for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture

InChi: InChI=1S/C19H13Cl4NO/c20-15-3-1-11(7-17(15)22)5-13-9-24-10-14(19(13)25)6-12-2-4-16(21)18(23)8-12/h1-8

Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM

CAS Number: 84468-24-6

BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 for a broad range ofBO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against