DL-TBOA Catalog No.:M18376-C SB590885 stabilizes the oncogenic B-Raf

SB590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration

Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer

Formula: C59H58ClN7O11

InChi: InChI=1S/C16H15N

DL-TBOA Catalog No.:M18376-C SB590885 stabilizes the oncogenic B-RafDL TBOA is a potent non transportable inhibitor of excitatory amino acid transporters with IC50s of 70 M, 6 M and 6 M for excitatory amino acid transporter 1 (EAAT1), EAAT2 and EAAT3, respectively. DL TBOA inhibits the uptake of [14C]glutamate in COS 1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 M and 5. 7 M, respectively. DL TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4. 4 M and 3. 2 M, respectively.