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Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities
CN(C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)OC(F)(F)F)C1=CC=NC(NC2C=CC=C(C=2)S(N)(=O)=O)=N1
it does cause drowsiness
ClH/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21
Liarozole dihydrochloride Size:Contact [email protected] for quotation Structure-guided design and optimization ofLiarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26) dependent 4 hydroxylation of RA (IC50=7 M), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties. Product information CAS Number: 1883548 96 6 Molecular Weight: 381. 69 Formula: C17H15Cl3N4 Chemical Name: 6 [(3