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Formula: C34H44N4O9
CAS Number: 71977-09-8
compound list : BAY-87-2243
Effect of BD 1047
LB-100 Catalog No.:M8527-10 Formula: C34H44N4O9LB 100 is a protein phosphatase 2A(PP2A)inhibitor. LB 100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. LB 100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments. LB 100 dramatically increased intracellular p Smad3 level, which was responsible for the effect of LB 100 as a sensitizer. LB 100 downregulated Bcl 2 expression and enhanced sorafenib
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