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with 32% and 44% inhibition at 5 and 20 mg/kg/day
OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity
Formula: C21H16ClF3N4O3
1009820-21-6
17-AAG Hydrochloride zithromycin with 32% and 44% inhibition17 AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100 fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild type androgen receptor (AR), leading to the RB dependent G1 growth arrest of prostate cancer cells. It has the ability to induce
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