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ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16
InChiKey: OJXYMYYDAVXPIK-IWKNALKQSA-N
265(5175):1093-5
InChi: InChI=1S/C10H8N4O5/c15-8-6-13(10(16)12-8)11-5-1-2-7-3-4-9(19-7)14(17)18/h1-5H
OG-L002 HCl 2623 ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16OG L002 is a specific and potent inhibitor of lysine (K) specific demethylase 1A (LSD1) with IC50 value of 20 nM . LSD1 is a flavin dependent monoamine oxidase, which can demethylate lysines. LSD1 plays critical roles in oocyte growth, embryogenesis and tissue specific differentiation . OG L002 potently inhibited HSV IE gene expression in both HFF and HeLa cells with IC50 of ~3 M and ~10 M, respectively. OG L002 treatment can potently reduce
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