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KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes
InChi: InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11
Formula: C13H20N4O7
InChi: InChI=1S/C14H17N5O2S/c20-13(19-6-2-1-3-7-19)9-15-14(21)16-10-4-5-11-12(8-10)22-18-17-11/h4-5
TUG-891 - CAS# 1374516-07-0 size:2mg solid KL001-mediated CRY stabilization inhibited glucagon-inducedTUG 891, CAS No. 1374516 07 0, is a potent and selective agonist of the free fatty acid receptor 4 (FFA4 GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG 891 also resulted in rapid phosphorylation and internalization of the receptor. TUG 891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo
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