UK-5099 - CAS# 56396-35-1 66052 SU5416 selectively inhibits VEGF-driven mitogenesis

SU5416 selectively inhibits VEGF-driven mitogenesis in a dose-dependent manner with IC50 of 0

ISRIB blocks multiple stress effectors

is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM)

and ALK7 (> 0

UK-5099 - CAS# 56396-35-1 66052 SU5416 selectively inhibits VEGF-driven mitogenesisUK 5099, CAS No. 56396 35 1, is a specific and potent mitochondrial pyruvate carrier blocker (MCK blocker). The UK5099 treated cells showed significantly higher proportion of side population (SP) fraction and expressed higher levels of stemness markers Oct3 4 and Nanog. Chemosensitivity examinations revealed that the UK5099 treated cells became more resistant to chemotherapy compared to the non treated cells. MPC blocker (UK5099) application may be an