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Protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins[2]
Takinib shows significant inhibitory activity (<10% enzyme activity after exposure) on six serine/threonine kinases
HBX41108 inhibits cancer cell growth
Motesanib treatment also induces significant dose-dependent reductions in tumor growth and blood vessel density of MCF-7
Afobazole Hydrochloride - CAS# 173352-39-1 Catalog No.:M11224-C Protopine is a novel microtubuleFabomotizole, also known as Afobazole, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO A reversibly
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