KHK-IN-1 hydrochloride astragaloside I Oral dosing of INCB28060 results

Oral dosing of INCB28060 results in time- and dose-dependent inhibition of c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models

(2015) Cell Stem Cell

Smiles: CC(C)N1CCC(CC1)NC1=NC(=NC2=CC(OCCCN3CCCC3)=C(C=C21)OC)N1CCC(F)(F)CC1

InChiKey: QZJHREOKMZFHTH-DRRXZNNHSA-N

KHK-IN-1 hydrochloride astragaloside I Oral dosing of INCB28060 resultsKHK IN 1 hydrochloride is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp 27B in the ATP binding region of KHK. Product information CAS Number: 1303470 48 5 Molecular Weight: 459. 01 Formula: C21H27ClN8S Chemical Name: N8 (cyclopropylmethyl) N4 [2 (methylsulfanyl)phenyl] 2 (piperazin 1 yl) [1,3]diazino[5,4 d]pyrimidine 4,8 diamine hydrochloride Smiles: Cl. CSC1=CC=CC=C1NC1=NC(=NC2C1=NC=NC=2NCC1CC1)N1CCNCC1 InChiKey: