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selectively binds to the prenyl-binding pocket of PDEδ with 38 nM affinity
CAS Number: 1420071-30-2
InChiKey: BIGPXXAUSQLTQR-UHFFFAOYSA-N
5S)-1-((S)-2-((1R
BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S selectively binds to the prenyl-bindingBIX 02188, CAS No. 334949 59 6, is a potent inhibitor of MEK5 (IC50 = 4. 3 nM) with reduced activity towards inhibition of ERK5 and TGFR1 (IC50s = 810 and 1, 800 nM, respectively). Inhibition of MEK5 by BIX 02188 induces apoptosis in cells expressing the oncogenic mutant FLT3 ITD. Product information CAS Number: 334949 59 6 Molecular Weight: 412. 48 Formula: C25H24N4O2 Chemical Name: (Z) 3 (((3 ((dimethylamino)methyl)phenyl)amino)(phenyl)methylene) 2
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