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Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=C(N)C2=C(F)C=CC=C2NC1=O
7)8)48(65)59-25-37(61)23-39(59)47(64)54-29(2)33-9-11-35(12-10-33)44-30(3)53-27-69-44/h9-16
LEE011 succinate hydrate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway
SMARCA4 and PBRM1 in MV-4-11 cells
Fotemustine cycline (hyclate) Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=C(N)C2=C(F)C=CC=C2NC1=OFotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1 guanine and N3 cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
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