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Epub 2010 Nov 26
EAI045 has high potency and selectivity for L858R/T790M mutation
AT-7519 trifluoroacetate
Torcetrapib
GSK3368715 dihydrochloride 14893 Epub 2010 Nov 26GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S adenosyl L methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3. 1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5. 7 nM (PRMT6), 1. 7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti cancer activity. Product
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