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and antiprotozoal properties
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
Chemical Name: 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylic acid
Kowalik-Jankowska T
CEP 1347 ITC and antiprotozoal propertiesCEP 1347, also called KT 7515, is an inhibitor of the c Jun N terminal kinase (JNK) signaling pathway, with an IC50 value for JNK1 activation of 20 2 nM in rat embryonic motoneurons . The JNK pathway, also known as the stress activated protein kinase (SAPK) pathway, is one of the signaling cascades that mediate the apoptotic death in response to a variety of stressful stimuli. JNK activation by phosphorylation is important for neuronal cell death
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