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3Caffeoylquinate
is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431
8400 pmol/g) and Tmax (≤0
SB-743921 (1
TW-37 Catalog No.:M7872-2 3CaffeoylquinateTW 37 is a small molecule inhibitor of Bcl 2 family proteins, inhibited cell growth and induced apoptosis in pancreatic cancer. TW 37 induces cell growth inhibition and S phase cell cycle arrest, with regulation of several important cell cycle related genes like p27, p57, E2F 1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch 1, Jagged 1, and its
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