K-Ras ligand-Linker Conjugate 5 G 149 KRIBB11 inhibits HSP70 synthesis through

KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter

Metronidazole is an antibiotic and antiprotozoal medication

Smiles: CN(C)C[C@@H](NC(=O)N1CC2C(NC(=O)C3C=CC(=CC=3)NC(=O)C=C)=NNC=2C1(C)C)C1C=CC=CC=1

InChi: InChI=1S/C36H46N8O3/c1-4-47-32-23-25(34(45)43-17-15-26(16-18-43)42-21-19-40(2)20-22-42)13-14-29(32)38-36-37-24-31-33(39-36)44(27-9-5-6-10-27)30-12-8-7-11-28(30)35(46)41(31)3/h7-8

K-Ras ligand-Linker Conjugate 5 G 149 KRIBB11 inhibits HSP70 synthesis throughK Ras ligand Linker Conjugate 5 incorporates a ligand for K Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K Ras ligand Linker Conjugate 5 can be used in the synthesis of PROTAC K Ras Degrader 1 (HY 129523), which is potent PROTAC K Ras degrader that exhibits 70% degradation efficacy in SW1573 cells. Product information CAS Number: 2378261 85 7 Molecular Weight: 789. 96 Formula: C42H59N7O8