ML334 CX4430 freebase Inhibition of RSK with the

Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells

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Smiles: NC1C=CC(=CC=1)S(=O)(=O)NC1=CC=NN1C1C=CC=CC=1

InChi: InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5

ML334 CX4430 freebase Inhibition of RSK with theML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1 NRF2 protein protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 M. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity. Product information CAS Number: 1432500 66 7 Molecular Weight: 446. 50 Formula: C26H26N2O5 Chemical Name: (1S,2R) 2 [(1S) 1 [(1,3 dioxo 2,3 dihydro 1H isoindol 2 yl)methyl]