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5 cell line
CC-115 shows good in vivo PK profiles across multiple species with 53%
in the tumors it remains at micromolar concentrations for at least 12 hours
Crenolanib inhibits [125I]-IAAP photocrosslinking of ABCB1 at high concentrations
YM-155 - a survivin inhibitor. CAS# 781661-94-7 0263 5 cell lineYM 155, CAS No. 781661 94 7, is a novel survivin suppressant with an IC50 of 0. 54 nM for the inhibition of survivin promoter activity. Sepantronium bromide, also known as YM 155, is a small molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and