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Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells
3-dimethyl-2-oxo-6-(piperidin-1-yl)-2
4S)-4-(17-amino-3
03) but not at the lower dose of 40 mg/kg (%T/C: 100%)
DC0-NH2 e olamine Conduritol B epoxide-N2a cells showDC0 NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0 NH2 is about 1000 fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0 NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. Product information CAS Number: 615538 51 7 Molecular Weight: 550. 01 Formula: C31H24ClN5O3 Chemical Name: 5 amino N {2 [(1S) 1