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6-dimethoxy-4-(2-methyl-1-oxo-1
abstr 3030
induces antitumor activity
22(2):963-8
PROTAC Sirt2 Degrader-1 0259 6-dimethoxy-4-(2-methyl-1-oxo-1Sirt2 PROTAC 1 is a SirReal based PROTAC, inducing isotype selective Sirt2 degradation. PROTAC Sirt2 Degrader 1 is composed of a highly potent and isotype selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader 1 shows an IC50 of 0. 25 M for Sirt2, with no effect on Sirt1 Sirt3 (IC50s>100 M). Product information CAS Number: 2098487 75 1 Molecular Weight: 852. 94 Formula: C40H40N10O8S2
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