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the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis
β-Nicotyrine Catalog No.:M22486-C the expression of pro-apoptotic Bcl2Nicotyrine is an alkaloid metabolite of nicotine as well as a major product of its pyrolysis., It binds comparably to two cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 (Kis = 7. 5 and 5. 6 M, respectively), which are prominently involved in the metabolism of xenobiotics in the airways. However, nicotyrine appears to more effectively inactivate CYP2A6, leaving only 49% activity after a 10 minute exposure with 20 M nicotyrine, as opposed to 87%
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