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at hydroxylation sites in the oxygen-dependent degradation domain (ODDD)
GSK269962A has an IC50 of 1
AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice
with IC50s of 370 nM
CP 640186 monohydrochloride - CAS# 591778-70-0 Size:2mg solid at hydroxylation sites in theCP 640186 monohydrochloride, CAS No. 591778 70 0, is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. CP 640186 has recently been shown to be a potent inhibitor of isoforms of mammalian ACCs with IC50 values of about 55 nM. This is currently the only reported potent inhibitor of mammalian ACCs. In cell cultures as well as in animal models, CP 640186 can reduce tissue malonyl CoA levels,
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