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except PRKG1α and PRKG1β with IC50 of 98 nM and 69 nM
277(34):30998-1004
X and DNA-PK-dependent pathway
OAC1 seems to enhance reprogramming efficiency in a unique manner
Harmine - DYRK1A Inhibitor. CAS# 442-51-3 size:10 mg solid except PRKG1α and PRKG1β withHarmine, CAS No. 442 51 3, is a potent, selective and orally bioavailable DYRK1A inhibitor with IC50 of 80 nM. It inhibits phosphorylation of tau directly by DYRK1A (IC50 ~700 nM). It has >10 fold selectivity over DYRK3 and DYRK2 (IC50 ~800 nM and 900 nM respectively. Harmine is also a unique regulator of PPAR expression that acts by inhibiting the Wnt signalling pathway in a cell specific manner. It attenuates inflammatory gene expression (TNF, IL 1,
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