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102(4):1458-65
PHT-427 reduces the phosphorylation of AKT and PDPK1
selective and orally available PORCN inhibitor
Like lamotrigine
PF-04217903 Size:2mg solid 102(4):1458-65PF 04217903 is a MET tyrosine kinase inhibitor, is also a n orally bioavailabe, small molecule tyrosine kinase inhibitor of the proto oncogene c Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c Met inhibitor PF 04217903 selectively binds to and inhibits c Met, disrupting the c Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction
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