MRK-016 IA 4-1-3(5)2-9-10(6

4-1-3(5)2-9-10(6

and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss

Selective inhibition of BET bromodomains

PNPLA3 and PPARα

MRK-016 IA 4-1-3(5)2-9-10(6MRK 016 is a selective, orally bioavailable inverse agonist of GABAA 5 receptor, with an EC50 of 3 nM for GABAA 5, and Kis of 0. 83, 0. 85, 0. 77 and 1. 4 nM for human GABAA 132, GABAA 232, GABAA 332, and GABAA 532, respectively; MRK 016 also readily penetrates the CNS. Product information CAS Number: 342652 67 9 Molecular Weight: 368. 39 Formula: C17H20N8O2 Chemical Name: 5 ({[3 tert butyl 7 (5 methyl 1,2 oxazol 3 yl)pyrazolo[1,5 d][1,2,4]triazin 2