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Dovitinib (10 mg/kg
(1998) Bioorg Med Chem Lett
SGC0946 is much more potent than its close analog EPZ004777
likely occupying a similar site within the ligand-binding domain
Rolapitant - CAS# 552292-08-7 Catalog No.:M6632-10 Dovitinib (10 mg/kgRolapitant, CAS No. 552292 08 7, also known as SCH 619734, is an orally bioavailable, centrally acting, selective, neurokinin 1 receptor (NK1 receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1 receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP induced emesis and