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Chemical Name: N-(4-((5-(3-(furan-2-ylmethyl)-4-oxo-1
Formula: C20H22ClNO4
Cocktail Formulation: 5 mM Thiazovivin
Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657
GSK-2606414 - CAS# 1337531-36-8 0435 Chemical Name: N-(4-((5-(3-(furan-2-ylmethyl)-4-oxo-1GSK 2606414, CAS No. 1337531 36 8, is an orally available, potent, and selective PERK inhibitor. GSK 2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR) like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
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