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CAS Number: 263707-16-0
MEK162 was orally dosed to mice at 3-30 mg/kg once per day
46(5):483-93
PubMed Central PMCID: PMC3163687
SB525334 - CAS# 356559-20-1 Catalog No.:M6900-2 CAS Number: 263707-16-0SB525334, CAS No. 356559 20 1, is a potent and selective inhibitor of the transforming growth factor beta1 (TGF beta1) receptor, activin receptor like kinase (ALK5). SB525334 inhibited ALK5 kinase activity with an IC(50) of 14. 3 nM and was approximately 4 fold less potent as an inhibitor of ALK4 (IC(50) = 58. 5 nM). SB 525334 was inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC(50) > 10, 000 nM). In cell based assays, SB 525334 (1 microM) blocked
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