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and induces G2/M-phase growth arrest and cell death through the induction of apoptosis
7-trihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
2-²H₄)ethyl]piperidin-4-yl})methanol hydrochloride
CAS Number: 915363-56-3
Endoxifen Z-isomer hydrochloride Size:Contact [email protected] for quotation and induces G2/M-phase growth arrestEndoxifen Z isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti estrogenic effects of this drug in breast cancer cells expressing estrogen receptor alpha (ER). Endoxifen inhibits hERG tail currents at 50 mV in a concentration dependent manner with IC50 values of 1. 6 M. IC50 value: 1. 6 M Target: hERG Potassium Channel, Estrogen Receptor ERREndoxifen is considered a prodrug, since it has a much higher
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