SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 size:10 mg solid is a pan-Janus-activated kinase inhibitor

is a pan-Janus-activated kinase inhibitor

SKPin C1 was used at 10 µM final concentration in various in vitro assays

The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins

Formula: C22H25N3O4

SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 size:10 mg solid is a pan-Janus-activated kinase inhibitorSW033291, CAS No. 459147 39 8, is a highly potent and selective inhibitor of 15 PGDH enzyme with IC50 1. 5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15 PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3. 5 fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue