VR23 - Proteasome Inhibitor. CAS# 1624602-30-7 433 Inhibitors of Hedgehog acyltransferase block

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

Smiles: CCCOC1C=CC(CCC2=NC3=CC(=CC=C3N2CCN2CCOCC2)C2C(C)=NOC=2C)=CC=1

Smiles: COC1=CC(=CC=C1C(O)=O)NC1=NC2=C(CN=C(C3=C(F)C=CC=C3OC)C3=CC(Cl)=CC=C32)C=N1

Nicholson JR

VR23 - Proteasome Inhibitor. CAS# 1624602-30-7 433 Inhibitors of Hedgehog acyltransferase blockVR23, CAS No. 1624602 30 7, is a potent and selective proteasome inhibitor with IC50 of 1 nM, 50 100 nM, and 3 M for trypsin like proteasomes, chymotrypsin like proteasomes, and caspase like proteasomes, respectively. Data from molecular docking and substrate competition assays established that the primary molecular target of VR23 was 2 of the 20S proteasome catalytic subunit. VR23 was structurally distinct from other known proteasome inhibitors and