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64 Suppl:S11-7
Compound401
In human leukemic B lymphocytes
which prevents the activation of PKC-mediated signaling pathways
Vincristine sulfate Size:2mg solid 64 Suppl:S11-7Vincristine sulfate is the sulfate salt of a natural alkaloid isolated from the periwinkle plant of the oleander family with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid,
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