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CAS Number: 1219707-39-7
Molecular Weight: 530
A phase I study of KPT-330in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia
protects against time-dependent cisplatin-induced inactivation of MTP
LEE011 succinate spimycin CAS Number: 1219707-39-7Ribociclib Free Base, also known as LEE011, is an orally available cyclin dependent kinase (CDK) inhibitor targeting cyclin D1 CDK4 and cyclin D3 CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4 6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK mediated G1 S phase transition, thereby arresting the cell cycle in the G1