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the combination of Dasatinib and GNF-2 overcame resistance of BCR/ABL-T315I in all models used in a synergistic manner
InChi: InChI=1S/C18H18N2O3/c1-11(2)18(22)20-16(14-6-4-10-23-14)13-8-7-12-5-3-9-19-15(12)17(13)21/h3-11
In the PC-3 model
InChi: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2
NLG919 (RG6078) - IDO Inhibitor. CAS# 1402836-58-1 0172 the combination of Dasatinib andNLG919, CAS No. 1402836 58 1, is a potent, selective and orally bioavailable IDO (indoleamine (2, 3) dioxygenase) pathway inhibitor with Ki ~7 nM (EC50 ~75 nM) in vitro and in cell based assays. Oral administration of NLG919 reduces the [Kyn] in plasma and tissue by ~ 50%. Using human IDO+ pDCs in allogeneic MLR reactions, NLG919 potently blocked IDO induced T cell suppression and restored robust T cell responses with an EC50 ~90 nM. NLG919 abrogated
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