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is a novel selective
1(10):1021-32
Smiles: CN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@@H](CO)OC1=O
In vitro characterization
TG 100572 Hydrochloride laconine is a novel selectiveTG 100572 is a potent and selective VEGFR2 Src kinase inhibitor. TG100572 inhibits Src kinases and selected receptor tyrosine kinases, induced apoptosis of proliferating endothelial cells in vitro. TG100572 inhibits downstream molecules involved in the vascular endothelial growth factor (VEGF) signaling pathway resulted in markedly diminished levels of HSV induced angiogenesis and significantly reduced the severity of SK lesions.. Product information
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