LEE011 succinate hydrate(1:1:x) Catalog No.:M9046-2 2-H)ethyl](2-chloroethyl)amino}-1-methyl-1H-1

2-H)ethyl](2-chloroethyl)amino}-1-methyl-1H-1

1 lung colonisation model

InChiKey: CZSLEMCYYGEGKP-UHFFFAOYSA-N

ML-329 could directly or indirectly interact with MITF or components of the MITF regulatory network

LEE011 succinate hydrate(1:1:x) Catalog No.:M9046-2 2-H)ethyl](2-chloroethyl)amino}-1-methyl-1H-1LEE011 succinate hydrate is an orally available cyclin dependent kinase (CDK) inhibitor targeting cyclin D1 CDK4 and cyclin D3 CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4 6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK mediated G1 S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing