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a natural alkaloid isolated from Piper nigrum L
and also induces significant cellular morphological changes
20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO
40(4):356-
Mal-Phe-C4-VC-PAB-MMAE 4975 a natural alkaloid isolated fromMal Phe C4 VC PAB MMAE is made by MMAE conjugated to Mal Phe C4 VC PAB linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. Product information CAS Number: 2259318 51 7 Molecular Weight: 1364. 67 Formula: C72H105N11O15 Chemical Name: {4 [(2S) 5 (carbamoylamino) 2 [(2S) 2 {4 [4 (2,5 dioxo 2,5 dihydro 1H pyrrol 1 yl)phenyl]butanamido} 3 methylbutanamido]pentanamido]phenyl}methyl N [(1S) 1
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