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ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22
Formula: C33H33N9O2
and is the first small molecule SMN2 splicing modifier to enter human clinical trials
PubMed Central PMCID: PMC4603616
DCG-IV Catalog No.:M20043-C ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22DCG IV is a potent agonist of group II mGluRs with EC50s of 0. 35 and 0. 09 M for mGlu2R and mGlu3R, reapectively. DCG IV is also a competitive antagonist at group I (IC50: mGlu1R 5R=389 630 M) and III receptors (IC50: mGlu4R 6R 7R 8R= 22. 5 39. 6 40. 1 32 M). DCG IV has anticonvulsive and neuroprotective effects. Product information CAS Number: 147782 19 2 Molecular Weight: 203. 15 Formula: C7H9NO6 Chemical Name: (1R,2R) 3 [(S)
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