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Ships within 48 hours · Estimated delivery Jul 30 - Aug 4
Formula: C18H12F6N6O
83 mg/mL (45
InChi: InChI=1S/C16H16N2O/c1-12-6-2-3-7-13(12)10-18-15-9-5-4-8-14(15)17-16(18)11-19/h2-9
InChi: InChI=1S/C19H20N2O3/c1-19(2
BI-3406 Size:10mg solid Formula: C18H12F6N6OBI 3406 is Potent & Selective SOS1:: KRAS Inhibitor (IC50=5 nM), which Opens a New Approach for Treating KRAS Driven Tumours. BI 3406 selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. BI 3406 causes RAS GTP and pERK reduction and inhibits cell growth of KRAS mutated cell lines, carrying most of the typical KRAS mutations (i. e. G12D, G12V, G13D and others). BI 3406, when administered orally to tumour
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