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1946833-85-7 (citrate)
MDV-3100 inhibits the transcriptional activity of a mutant AR protein (W741C
CC-115 shows good in vivo PK profiles across multiple species with 53%
It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 1
PF-06463922 5109 HCl 1946833-85-7 (citrate)Lorlatinib, also known as PF 06463922, is an orally available, ATP competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, ALK ROS1 inhibitor PF 06463922 binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK and ROS1 mediated signaling and eventually inhibits tumor cell growth in ALK and