Pay in 4 interest-free payments of $5.00 Learn more
Ships within 48 hours · Estimated delivery Jul 27 - Aug 1
177(4):1067-1079
Caspase-9 cleavage
immunoblotting of protein lysates from C33A-2D2 cells stimulated with SJ000291942 at different times is performed
Smiles: CN1CCN(CC1)C1=CC(NC2CCOCC2)=C(C=C1)C(=O)NC1=NNC2=CC=C(CC3C=C(F)C=C(F)C=3)C=C21
JHU 37160 - CAS# 2369979-68-8 60202 177(4):1067-1079JHU 37160, CAS No. 2369979 68 8, is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25 fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1 expressing neurons, and increases hM3Dq stimulated locomotion in rats