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11)12)5-9-13-6(10)8-3/h5H
Smiles: NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey: DGGQUKOLHQXDLV-QTNXRKSWSA-N
17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5
AP14145 hydrochloride Size:Contact [email protected] for quotation 11)12)5-9-13-6(10)8-3/h5HAP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1. 1 M for KCa2. 2 (SK2) and KCa2. 3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant resistant porcine model of atrial fibrillation (AF). Product
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