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[Epub ahead of print] PubMed PMID: 26317790
Saturday G
including human T-cell acute lymphoblastic leukaemia (T-ALL)
Tyler Lahusen
ETC-159 - CAS# 1638250-96-0 210 [Epub ahead of print] PubMedETC 159, CAS No. 1638250 96 0, also known as ETC 1922159, is a potent, selective and orally available PORCN inhibitor. ETC 159 blocks the secretion and activity of all Wnts. ETC 159 is remarkably effective in treating RSPO translocation bearing colorectal cancer (CRC) patient derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is