Mitoxantrone - CAS# 65271-80-9 035 Alterations in the intrinsic burst

Alterations in the intrinsic burst activity of Purkinje neurons in offspring maternally exposed to the CB1 cannabinoid agonist WIN 55212-2

2017024522

apoptosis and enhanced sensitivity to ionizing radiation

PubMed Central PMCID: PMC4866744

Mitoxantrone - CAS# 65271-80-9 035 Alterations in the intrinsic burstMitoxantrone, CAS No. 65271 80 9, is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5. 3 M), thus inhibiting cell proliferation. It also inhibits HIV 1 integrase (IC50 = 3. 8 M). Mitoxantrone is exported from cells in an ATP and glutathione dependent manner by multidrug resistance protein 1. 4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis. Product information CAS