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Supports mechanistic studies of TNF-R1/TNF-R2-mediated immune signaling and downstream pathway activation
and provides standardized results
P114630-WB-1-P
They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation
Recombinant Human IL-1α Protein Package Size:10μg Supports mechanistic studies of TNF-R1/TNF-R2-mediatedDescription IL 1 is a pleiotropic proinflammatory cytokine and core member of the IL 1 superfamily. Constitutively expressed as a precursor in epithelial cells (particularly dermal keratinocytes), it is proteolytically activated by calpain into a 17 kDa mature form that engages dual receptor mechanisms (IL 1R signaling IL 1R decoy) to trigger NF B and MAPK pathways, inducing cascading release of inflammatory mediators including IL 6, COX 2, and nitric
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