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Pyridostatin TFA induces the formation of DNA DSBs
InChi: InChI=1S/C19H21N3O3S/c1-22(2)26(24
O-Desmethylvenlafaxine
Fasudil Hydrochloride (100 μM) inhibits cell spreading
PFI-2 Hydrochloride 60099 Pyridostatin TFA induces the formationPFI 2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000 fold selectivity over other methyltransferases and other non epigenetic targets. PFI 2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI 2 interacts with SETD7 in pull down studies. Its enantiomer (S) PFI 2 is 500 fold less active making it an excellent negative control. Treatment of low density MEFs with (R) PFI 2 resulted in higher nuclear YAP levels indicating an
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