mewtwo holo pokemon card VSTAR 86/78 - Pokmon GO Holofoil including damage 2002 Neo Destiny Shining Mewtwo

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In Commander specifically, wiping artifacts in addition to creatures can really, really hamper some decks ability to come back from wipe and cripple them for turns

Things like Massacre Wurm or Sheoldred, Whispering One come to mind

Ferropede Ferropede is an unblockable little insect that chips in every turn