Spadin ptor Ligand M35 TFA Discovery of type II inhibitors

Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Molecular Weight: 3177

a small molecule that combines the Hsp90 ATPase inhibitory module of 17-allylamino geldanamycin (17-AAG) with the mitochondrial-targeting moiety of triphenylphosphonium

1222998-36-8

Spadin ptor Ligand M35 TFA Discovery of type II inhibitorsSpadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK 1 (KCNK2 or K2P2. 1) channel activity. Spadin binds specifically to TREK 1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice. Product information CAS Number: 1270083 24 3 Molecular Weight: 2012. 32 Formula: C96H142N26O22 Chemical Name: (2S) 2 [(2S) 2 {2 [(2S) 2 [(2S) 2 [(2S) 2 {2 [(2S,3S) 2 {[(2S) 1 {2 [(2S) 2 [(2S) 2 [(2S) 2 {[(2S)